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Neos Flow (formerly TYPO3 Flow) is a powerful PHP web application framework designed for creating scalable and robust applications. It follows modern development principles like domain-driven design, command query responsibility segregation, and aspect-oriented programming. Flow provides a comprehensive set of features including dependency injection, a powerful object-relational mapper, and a flexible MVC architecture. It's particularly well-suited for complex, enterprise-level applications and serves as the foundation for the Neos Content Management System.

Play Framework is an open-source web application framework written in Scala and Java which follows the model-view-controller (MVC) architectural pattern. It aims to optimize developer productivity by using convention over configuration, hot code reloading, and display of errors in the browser. Play supports asynchronous programming patterns, making it suitable for building scalable, reactive applications. It integrates well with both Java and Scala ecosystems and provides features like built-in testing support, database access layers, and RESTful APIs out of the box.

Spring Framework is a comprehensive programming and configuration model for modern Java-based enterprise applications. It's applicable on any deployment platform and provides infrastructure support at the application level, allowing developers to focus on business logic. Spring's core features can be used by any Java application, but there are extensions for building web applications on top of the Java EE platform. Notable features include dependency injection, aspect-oriented programming, and simplified data access. Spring also offers additional projects that extend its capabilities to areas like security, cloud computing, and big data.